SynTumor是一种3D组织模型，用于在生理和形态学上逼真的肿瘤微环境中实时可视化和定量评估细胞 - 细胞和细胞 - 药物相互作用。该系统使（a）微脉管系统中的循环，（b）跨血管壁的运输，以及（c）输送到肿瘤。从扫描与间质和组织/肿瘤空间相结合的血管网络开始，SynTumor 3D组织模型创建了类似于可行组织学切片的体外肿瘤微环境。
特征
1.并排架构可实现定量实时可视化 2.具有工程多孔结构的生理渗漏性脉管系统 3.基于形态学逼真的体内建筑 4.生理上真实的对流和扩散传输 5.具有超低耗材体积的微流控平台参考文献
1.Rapid Assessment of Nanoparticle Extravasation in a Microfluidic Tumor Model
Author(s): Mai N. Vu, Pradeep Rajasekhar, Daniel P. Poole, Song Yang Khor, Nghia P. Truong, Cameron J. Nowell, John F. Quinn, Michael Whittaker, Nicholas A. Veldhuis, and Thomas P. Davis.ACS Applied Nano Materials 2 (4), 1844-1856 (2019).
2.A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy.
Author(s): Shantanu Pradhan, Ashley M. Smith, Charles J. Garson, Iman Hassani, Wen J. Seeto, Kapil Pant, Robert D. Arnold, Balabhaskar Prabhakarpandian & Elizabeth A. Lipke.Scientific Reports Volume 8, Article number: 3171(2018)
3.A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems
Author(s): Yuan Tang, Fariborz Soroush, Joel B. Sheffield, Bin Wang, Balabhaskar Prabhakarpandian & Mohammad F. Kiani Scientific Reports 7, Article number: 9359 (2017)
4.Microfluidic Co-Culture Devices To Assess Penetration Of Nanoparticles Into Cancer Cell Mass
Author(s): Jarvis M, Arnold M, Ott J, Pant K, Prabhakarpandian B, Mitragotri S.Bioeng Transl Med. 2017 Sep 26;2(3):268-277
5.Rational Design And Development Of A Peptide Inhibitor For The PD-1/PD-L1 Interaction
Author(s): Rebecca J. Boohaker, Vijaya Sambandam, Isaac Segura, James Miller, Mark Suto, Bo Xu Cancer Letters 434 (2018) 11e21
6.Synthetic Tumor Networks for Screening Drug Delivery Systems
Author(s): B. Prabhakarpandian, MC Shen, J. Nichols, C. Garson, I. Mills, M. Matar, J. Fewell, K. Pant.